Hydrochloric Acid → HCID 68930911, compound

HRID 1027454Notes

Reaction equation

HRID 1027454 reaction equation
[CH:1]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[C@@H:16]([CH3:28])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>O1CCOCC1>[ClH:29].[ClH:29].[CH:1]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]([OH:23])=[O:22])[C@@H:16]([CH3:28])[CH2:15]1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68928242HCID 68928242, compound

Product 1

HCID 68930911HCID 68930911, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of (S)-tert-butyl 2-(4-benzhydryl-2-methylpiperazin-1-yl)acetate (340 mg, 894 μmol) in 3 mL of 1,4-dioxane and 1 mL of concentrated HCl solution (37%) was stirred at rt overnight. The solvent was evaporated to dryness and the residue was crashed out of ether to give (S)-2-(4-benzhydryl-2-methylpiperazin-1-yl)acetic acid dihydrochloride as a white solid. MS (ESI, pos. ion) m/z: 325 (M+1).

Workup

  1. customThe solvent was evaporated to dryness

Sources & evidence

ORD record
ord-e63708e91cf24278ba52e565ab9ef7da
Source dataset
uspto-grants-2014_05
Patent number
US08735383B2

Reaction notes

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