Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | Heptane | HCID 8900 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 67177108 | HCID 67177108 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 58382528 | HCID 58382528 | 22.4% |
Reaction Steps
28 mg of potassium carbonate and 21 mg of 1-bromo-propane were added to a solution of 60 mg of 5-(4-chloro-benzyl)-2-(3-fluoro-phenyl)-6H-oxazolo[5,4-d]pyrimidin-7-one in 3 ml of dimethylformamide, and the reaction mixture was stirred at 60° C. for 16 h. After cooling, the mixture was subjected to chromatography (silica gel, gradient from heptane to heptane/ethyl acetate 3:1). 15 mg of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08735387B2 |
|---|
| Source dataset | uspto-grants-2014_05 |
|---|
| ORD ID | ord-0610ab101f7748988b8ff6b6cc3f98b0 |
|---|
| Source note | uspto-grants-2014_05 |
|---|
