HCID 67175746, compound → HCID 44633595, compound

HRID 1027504Notes

Reaction equation

HRID 1027504 reaction equation
C([O:5][C:6](=[O:42])[CH2:7][NH:8][C:9](=[O:41])[CH2:10][O:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([C:19]2[O:20][C:21]3[N:22]=[C:23]([CH2:32][C:33]4[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=4)[N:24]=[C:25]([O:28][CH2:29][CH2:30][CH3:31])[C:26]=3[N:27]=2)=[CH:14][C:13]=1[CH3:40])(C)(C)C>FC(F)(F)C(O)=O>[Cl:39][C:36]1[CH:35]=[CH:34][C:33]([CH2:32][C:23]2[N:24]=[C:25]([O:28][CH2:29][CH2:30][CH3:31])[C:26]3[N:27]=[C:19]([C:15]4[CH:16]=[C:17]([CH3:18])[C:12]([O:11][CH2:10][C:9]([NH:8][CH2:7][C:6]([OH:42])=[O:5])=[O:41])=[C:13]([CH3:40])[CH:14]=4)[O:20][C:21]=3[N:22]=2)=[CH:38][CH:37]=1

Participants

3

Reactant 1

HCID 67175746HCID 67175746, compound

Product 1

HCID 44633595HCID 44633595, compoundYield 81.7%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

50 mg of (2-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetylamino)-acetic acid tert-butyl ester were dissolved in 1 ml of trifluoroacetic acid and the mixture was stirred for 30 min. Then the solvent was removed in vacuo to yield 37 mg of the title compound.

Workup

  1. customThen the solvent was removed in vacuo

Sources & evidence

ORD record
ord-727a972e5eb04bce95a850600fdf02b3
Source dataset
uspto-grants-2014_05
Patent number
US08735387B2

Reaction notes

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