Dipropyl disulfide → HCID 178460778, compound

HRID 1027517Notes

Reaction equation

HRID 1027517 reaction equation
[CH3:1][S:2][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][NH:6][CH:7]=1.[CH2:14](SSCCC)[CH2:15]C.BrC1C(C2C=NC=CC=2)=NNC=1>C(OCC)(=O)C.C(OCC)C>[CH2:1]([S:2][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][NH:6][CH:7]=1)[CH2:14][CH3:15]

Participants

5

Reactant 3

HCID 12377Dipropyl disulfideHCID 178419464HCID 178419464, compound2×HCID 178503312HCID 178503312, compound

Product 1

HCID 178460778HCID 178460778, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 21584169Diethylether ethylacetateSolvent

Procedure

Compound 21E was prepared following the procedure as described for the synthesis of compound 21A using (see scheme 3) 1-propyldisulfanyl-propane as the disulfide and 3-(4-bromo-1H-pyrazol-3-yl)-pyridine (compound 20A). (flash chromatography conditions ethyl acetate/diethyl ether 5/1).

Sources & evidence

ORD record
ord-8f4acae8420f46a7afa9ac9f8a8c86b4
Source dataset
uspto-grants-2014_05
Patent number
US08735388B2

Reaction notes

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