4-(5-(3,5-Dichlorophenyl)-5-(tri fluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid → HCID 68267481, compound

HRID 1027590Notes

Reaction equation

HRID 1027590 reaction equation
C(O[C:6](=[O:24])[NH:7][CH2:8][CH:9]1[S:13](=[O:15])(=[O:14])[N:12]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:11][CH2:10]1)(C)(C)C.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2([C:48]([F:51])([F:50])[F:49])[O:37][N:36]=[C:35]([C:38]3[CH:46]=[CH:45][C:41](C(O)=O)=[C:40]([CH3:47])[CH:39]=3)[CH2:34]2)[CH:29]=[C:30]([Cl:32])[CH:31]=1>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2([C:48]([F:50])([F:49])[F:51])[O:37][N:36]=[C:35]([C:38]3[CH:46]=[CH:45][C:41]([C:6]([NH:7][CH2:8][CH:9]4[S:13](=[O:14])(=[O:15])[N:12]([C:16]5[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=5)[CH2:11][CH2:10]4)=[O:24])=[C:40]([CH3:47])[CH:39]=3)[CH2:34]2)[CH:29]=[C:30]([Cl:32])[CH:31]=1

Participants

3

Reactant 2

HCID 231598114-(5-(3,5-Dichlorophenyl)-5-(tri fluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acidHCID 68267480HCID 68267480, compound

Product 1

HCID 68267481HCID 68267481, compoundYield 37.5%

Procedure

The compound obtained in Step C (94 mg) was deprotected and coupled with 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid (0.125 g) (prepared according to WO 2009/080250) as described in Example 4, Steps B and C to afford the title compound as a brown solid (65 mg). LCMS (Method F) 2.02 min, M−H 654/655.

Sources & evidence

ORD record
ord-91b6e872a07f473eb985931cc2ee7380
Source dataset
uspto-grants-2014_05
Patent number
US08735362B2

Reaction notes

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