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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1027590Generated: November 3, 2026

4-(5-(3,5-Dichlorophenyl)-5-(tri fluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid → HCID 68267481, compound

https://huagongshe.com/reaction/1027590

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(5-(3,5-Dichlorophenyl)-5-(tri fluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acidHCID 23159811—
ReactantHCID 68267480HCID 68267480—
ProductHCID 68267481HCID 6826748137.5%

Reaction Steps

The compound obtained in Step C (94 mg) was deprotected and coupled with 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid (0.125 g) (prepared according to WO 2009/080250) as described in Example 4, Steps B and C to afford the title compound as a brown solid (65 mg). LCMS (Method F) 2.02 min, M−H 654/655.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08735362B2
Source datasetuspto-grants-2014_05
ORD IDord-91b6e872a07f473eb985931cc2ee7380
Source noteuspto-grants-2014_05