Bromide ion → Methyl 5-(4-fluorophenyl)-1-(3-hydroxy-3-methylbutan-2-yl)-6-oxo-1,6-dihydropyridine-3-carboxylate

HRID 102768Notes

Reaction equation

HRID 102768 reaction equation
[Br-:24].[CH3:25][Mg+:26].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][c:10]([C:20](=[O:21])[O:22][CH3:23])[cH:11][n:12]([CH:15]([CH3:16])[C:17]([CH3:18])=[O:19])[c:13]2=[O:14])[cH:6][cH:7]1.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][c:10]([C:20](=[O:21])[O:22][CH3:23])[cH:11][n:12]([CH:15]([CH3:16])[C:17]([CH3:18])([OH:19])[CH3:25])[c:13]2=[O:14])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 67338493Methyl 5-(4-fluorophenyl)-6-oxo-1-(3-oxobutan-2-yl)-1,6-dihydropyridine-3-carboxylateHCID 178477777HCID 178477777, compound

Product 1

HCID 67338292Methyl 5-(4-fluorophenyl)-1-(3-hydroxy-3-methylbutan-2-yl)-6-oxo-1,6-dihydropyridine-3-carboxylate

Sources & evidence

ORD record
ord-16abcce327524874b67ecc0d2fce33b5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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