5-Methoxypyrazin-2-amine → 5-(6-((5-methoxypyrazin-2-yl)carbamoyl)-2-methylbenzofuran-4-yloxy)-N,N-dimethylpyrimidine-2-carboxamide

HRID 1027709Notes

Reaction equation

HRID 1027709 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[CH3:10][N:11]([CH3:36])[C:12]([C:14]1[N:19]=[CH:18][C:17]([O:20][C:21]2[C:26]3[CH:27]=[C:28]([CH3:30])[O:29][C:25]=3[CH:24]=[C:23]([C:31](OCC)=[O:32])[CH:22]=2)=[CH:16][N:15]=1)=[O:13]>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH:9][C:31]([C:23]2[CH:22]=[C:21]([O:20][C:17]3[CH:18]=[N:19][C:14]([C:12]([N:11]([CH3:10])[CH3:36])=[O:13])=[N:15][CH:16]=3)[C:26]3[CH:27]=[C:28]([CH3:30])[O:29][C:25]=3[CH:24]=2)=[O:32])=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 145364295-Methoxypyrazin-2-amineHCID 59483316Ethyl 4-(2-(dimethylcarbamoyl)pyrimidin-5-yloxy)-2-methylbenzofuran-6-carboxylate

Product 1

HCID 468938075-(6-((5-methoxypyrazin-2-yl)carbamoyl)-2-methylbenzofuran-4-yloxy)-N,N-dimethylpyrimidine-2-carboxamide

Procedure

The title compound (3) was prepared by a method analogous to that described in Example 1 using 5-methoxypyrazin-2-amine and ethyl 4-(2-(dimethylcarbamoyl)-pyrimidin-5-yloxy)-2-methylbenzofuran-6-carboxylate (I-2a).

Sources & evidence

ORD record
ord-bc1fd24131934f3dafaba3a5adbc7fe7
Source dataset
uspto-grants-2014_05
Patent number
US08735396B2

Reaction notes

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