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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1027709Generated: October 27, 2026

5-Methoxypyrazin-2-amine → 5-(6-((5-methoxypyrazin-2-yl)carbamoyl)-2-methylbenzofuran-4-yloxy)-N,N-dimethylpyrimidine-2-carboxamide

https://huagongshe.com/reaction/1027709

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methoxypyrazin-2-amineHCID 14536429—
ReactantEthyl 4-(2-(dimethylcarbamoyl)pyrimidin-5-yloxy)-2-methylbenzofuran-6-carboxylateHCID 59483316—
Product5-(6-((5-methoxypyrazin-2-yl)carbamoyl)-2-methylbenzofuran-4-yloxy)-N,N-dimethylpyrimidine-2-carboxamideHCID 46893807—

Reaction Steps

The title compound (3) was prepared by a method analogous to that described in Example 1 using 5-methoxypyrazin-2-amine and ethyl 4-(2-(dimethylcarbamoyl)-pyrimidin-5-yloxy)-2-methylbenzofuran-6-carboxylate (I-2a).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08735396B2
Source datasetuspto-grants-2014_05
ORD IDord-bc1fd24131934f3dafaba3a5adbc7fe7
Source noteuspto-grants-2014_05