HCID 68007300, compound → HCID 68006986, compound

HRID 1027793Notes

Reaction equation

HRID 1027793 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:23]=[C:22]3[C:18]([N:19]([C:26]([N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[O:27])[C:20](=[O:25])[N:21]3[CH3:24])=[CH:17][N:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[N:23]=[C:22]3[C:18]([N:19]([C:26]([N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)=[O:27])[C:20](=[O:25])[N:21]3[CH3:24])=[CH:17][N:16]=2)[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 68007300HCID 68007300, compound

Product 1

HCID 68006986HCID 68006986, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3-benzyloxyphenyl)-9-methyl-7-(pyrrolidin-1-ylcarbonyl)-7,9-dihydro-8H-purine-8-one <the compound of Example 202> (30 mg) in methanol (10 ml) was added 10% palladium on carbon (3 mg) and the mixture was stirred for 4 hours at room temperature under hydrogen atmosphere. After removing the catalyst from the reaction mixture, the solvent was evaporated under reduced pressure, and the residue was dried to give the title compound 24 mg.

Workup

  1. customAfter removing the catalyst from the reaction mixture
  2. customthe solvent was evaporated under reduced pressure
  3. customthe residue was dried

Sources & evidence

ORD record
ord-c1f3ecae744140babbc8fac1f1e360f5
Source dataset
uspto-grants-2014_05
Patent number
US08735406B2

Reaction notes

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