HCID 68006945, compound → HCID 68007030, compound

HRID 1027795Notes

Reaction equation

HRID 1027795 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:18]=[C:17]3[C:13]([N:14]([C:21]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)=[O:22])[C:15](=[O:20])[N:16]3[CH3:19])=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[N:18]=[C:17]3[C:13]([N:14]([C:21]([N:23]4[CH2:24][CH2:25][CH2:26][CH2:27]4)=[O:22])[C:15](=[O:20])[N:16]3[CH3:19])=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 68006945HCID 68006945, compound

Product 1

HCID 68007030HCID 68007030, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3-nitrophenyl)-9-methyl-7-(pyrrolidin-1-ylcarbonyl)-7,9-dihydro-8H-purine-8-one <the compound of Example 203> (41 mg) in methanol (10 ml) was added 10% palladium on carbon (10 mg) and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. After removing the catalyst from the reaction mixture, the solvent was evaporated under reduced pressure, and the residue was dried to give the title compound 35 mg.

Workup

  1. customAfter removing the catalyst from the reaction mixture
  2. customthe solvent was evaporated under reduced pressure
  3. customthe residue was dried

Sources & evidence

ORD record
ord-4d2f5141dc1341a085ca79ac56e314ce
Source dataset
uspto-grants-2014_05
Patent number
US08735406B2

Reaction notes

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