反应详情

温度

90 °C

To 6-methoxy-1H-indole-3-carbonitrile (98.2 g, 0.57 mol) was added cesium carbonate (430 g, 1.32 mol), DMF (165 mL) and cyclobutylbromide (96%, 67.5 mL, 0.69 mol). The mixture was heated to 90° C. and stirred overnight. The mixture was cooled to 37° C. and poured into ice water (500 mL), washing in with water. After stirring for 1 hour the precipitate was collected on a filter and dried under a stream of nitrogen to give 1-cyclobutyl-6-methoxy-1H-indole-3-carbonitrile as a tan solid (124.1 g, 96%).

1. temperatureThe mixture was cooled to 37° C.
2. washwashing in with water
3. stirringAfter stirring for 1 hour the precipitate
4. customwas collected on
5. filtrationa filter
6. customdried under a stream of nitrogen