反应详情

温度

80 °C

N-(3-bromo-5-nitrophenyl)acetamide (4 g, 15.44 mmol) was dissolved in ethanol (154 mL) and saturated NH4Cl(aq) (2 mL). Iron (2.59 g, 46.3 mmol) was added to the solution the reaction mixture was heated to 80° C. for 30 minutes. Upon completion, the reaction was cooled to room temperature and filtered through a short pad of silica gel (ethyl acetate wash). The organic was dried over sodium sulfate, filtered, and concentrated under reduced pressure. N-(3-amino-5-bromophenyl)acetamide was isolated as a beige foam (3.25 g, 14.19 mmol, 92%).

1. temperatureUpon completion, the reaction was cooled to room temperature
2. filtrationfiltered through a short pad of silica gel (ethyl acetate wash)
3. dry with materialThe organic was dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure