Bromine → 4-Bromo-2,2,5,5-tetramethyldihydrofuran-3(2h)-one

참여 물질

반응 단계

To a solution of 2,2,5,5-tetramethyldihydrofuran-3(2H)-one (Aldrich) (10.0 g, 0.07 mol) in dichloromethane (100 mL) was added bromine (3.6 mL, 0.07 mol) drop wise at room temperature. The reaction mixture was stirred for 2 hours as the brown reaction mixture became a clear solution. The reaction mixture was quenched with the addition of NaHCO3 powder in small portions, filtered and concentrated to provide the title compound as viscous oil (14.1 g, 90%).

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