Bromine → 4-Bromo-2,2,5,5-tetramethyldihydrofuran-3(2h)-one

HRID 1028163Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1028163
[CH3:1][C:2]1([CH3:10])[C:6](=[O:7])[CH2:5][C:4]([CH3:9])([CH3:8])[O:3]1.[Br:11]Br>ClCCl>[Br:11][CH:5]1[C:4]([CH3:9])([CH3:8])[O:3][C:2]([CH3:10])([CH3:1])[C:6]1=[O:7]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 1385112,2,5,5-Tetramethyltetrahydro-3-ketofuran

Produkt 1

HCID 122017454-Bromo-2,2,5,5-tetramethyldihydrofuran-3(2h)-oneAusbeute 91,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2,2,5,5-tetramethyldihydrofuran-3(2H)-one (Aldrich) (10.0 g, 0.07 mol) in dichloromethane (100 mL) was added bromine (3.6 mL, 0.07 mol) drop wise at room temperature. The reaction mixture was stirred for 2 hours as the brown reaction mixture became a clear solution. The reaction mixture was quenched with the addition of NaHCO3 powder in small portions, filtered and concentrated to provide the title compound as viscous oil (14.1 g, 90%).

Aufarbeitung

  1. customThe reaction mixture was quenched with the addition of NaHCO3 powder in small portions
  2. filtrationfiltered
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b70d2cd4e9b6489ea707ce4b13969987
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735434B2

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