HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 3-(cyclobutylmethyl)-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | 3-Oxotetrahydrofuran | HCID 529392 | — |
| Reactant | 1-Cyclobutylmethanamine hydrochloride | HCID 21707944 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-(cyclobutylmethyl)-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine | HCID 69231135 | — |
Reaction Steps
Commercially available dihydrofuran-3(2H)-one (Small Molecules Inc.), triethylamine, cyclobutylmethanamine hydrochloride (prepared from cyclobutanecarbonitrile as described in WO 2005075464), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 17A to afford the title compound. LC/MS (ESI+) m/z 211 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735434B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-88a498b144e54f68b284fa4d422ce014 |
| Source note | uspto-grants-2014_05 |