Iodine → 3-(cyclobutylmethyl)-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine

HRID 1028182Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1028182
[O:1]1[CH2:5][CH2:4][C:3](=O)[CH2:2]1.Cl.[CH:8]1([CH2:12][NH2:13])[CH2:11][CH2:10][CH2:9]1.[S-:14][C:15]#[N:16].[K+].II>C(N(CC)CC)C>[CH:8]1([CH2:12][N:13]2[C:3]3[CH2:2][O:1][CH2:5][C:4]=3[S:14][C:15]2=[NH:16])[CH2:11][CH2:10][CH2:9]1

Komponenten

6

Edukt 4

HCID 807IodineHCID 516872Potassium thiocyanateHCID 5293923-OxotetrahydrofuranHCID 217079441-Cyclobutylmethanamine hydrochloride

Produkt 1

HCID 692311353-(cyclobutylmethyl)-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

Commercially available dihydrofuran-3(2H)-one (Small Molecules Inc.), triethylamine, cyclobutylmethanamine hydrochloride (prepared from cyclobutanecarbonitrile as described in WO 2005075464), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 17A to afford the title compound. LC/MS (ESI+) m/z 211 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-88a498b144e54f68b284fa4d422ce014
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08735434B2

Notizen zur Reaktion

Wird geladen…