反应详情

A 1 N hydrochloric acid (250 mL)/acetone (250 mL) mixed solution of cis-7-methyl-1,4-dioxa-spiro[4.5]-decan-8-ol (19.9 g) obtained in Example (14a) was stirred at room temperature for 16 hours. The organic solvent was removed under reduced pressure. The remaining aqueous mixture was subjected to 6 extractions with ethyl acetate. The organic layer was washed with saturated brine, then dried over sodium sulfate, and then concentrated. The residue was dried under reduced pressure to obtain the title compound (14.4 g, 97%) as a colorless oil.

1. customThe organic solvent was removed under reduced pressure
2. extractionThe remaining aqueous mixture was subjected to 6 extractions with ethyl acetate
3. washThe organic layer was washed with saturated brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe residue was dried under reduced pressure