Hydrochloric Acid → cis-4-Hydroxy-3-methyl-cyclohexanone

Participants

Reaction Steps

A 1 N hydrochloric acid (250 mL)/acetone (250 mL) mixed solution of cis-7-methyl-1,4-dioxa-spiro[4.5]-decan-8-ol (19.9 g) obtained in Example (14a) was stirred at room temperature for 16 hours. The organic solvent was removed under reduced pressure. The remaining aqueous mixture was subjected to 6 extractions with ethyl acetate. The organic layer was washed with saturated brine, then dried over sodium sulfate, and then concentrated. The residue was dried under reduced pressure to obtain the title compound (14.4 g, 97%) as a colorless oil.

Provenance & Evidence