Sodium Methoxide → HCID 178490920, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C@H:14]3[CH2:19][CH2:18][C@H:17]([O:20]C(=O)C4C=CC=CC=4)[CH2:16][CH2:15]3)=[N:9]2)=[CH:5][CH:4]=1.C[O-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C@H:14]3[CH2:19][CH2:18][C@H:17]([OH:20])[CH2:16][CH2:15]3)=[N:9]2)=[CH:5][CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a methanol (10 mL) solution of trans-benzoic acid 4-[2-(4-methoxy-benzyl)-2H-tetrazol-5-ylmethyl]-cyclohexyl ester (610 mg) obtained in Example (44c), sodium methoxide (28% methanol solution, 0.29 mL) was added at room temperature. After 2 days, the reaction mixture was concentrated. The residue was purified by column chromatography (hexane/ethyl acetate=5:1→1:1 and then dichloromethane/methanol=50:1) to obtain the title compound (396 mg, 87%) as a colorless oil.