Acetanilide → HCID 25216870, compound

HRID 1028385Notes

Reaction equation

HRID 1028385 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-])=O.[C:12]1([NH:18][C:19](=O)[CH3:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]2[N:9]=[C:19]([CH3:20])[N:18]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:2]=2[CH:7]=1

Participants

3

Reactant 2

HCID 904AcetanilideHCID 27569932-Bromo-4-fluoro-1-nitrobenzene

Product 1

HCID 25216870HCID 25216870, compoundYield 66%

Procedure

The title compound was prepared with the analogous procedure described in example 3 using 1-Bromo-5-fluoro-2-nitrobenzene and N-phenylacetamide (81 mg, 0.6 mmol) as starting materials to yield the title compound as brown solid (75 mg, 66%). 1H NMR (DMSO) δ 2.50 (s, 3 H), 7.11 (d, 1 H), 7.21-7.29 (m, 1H), 7.59-7.69 (m, 5 H), 7.79 (br s, 1 H).

Workup

  1. customThe title compound was prepared with the analogous procedure

Sources & evidence

ORD record
ord-43645468bd1448648ad18c8631b90f43
Source dataset
uspto-grants-2014_05
Patent number
US08735586B2

Reaction notes

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