Hydrochloric Acid → HCID 67491354, compound

HRID 1028445Notes

Reaction equation

HRID 1028445 reaction equation
Cl.[C:2]([C:6]1[CH:7]=[C:8]([C:45]([O:47][CH3:48])=[O:46])[C:9]([O:43][CH3:44])=[C:10]([NH:12][C:13]([C:15]2[CH:16]=[CH:17][C:18]([CH3:42])=[C:19]([CH:41]=2)[O:20][C:21]2[CH:26]=[CH:25][N:24]=[C:23]([CH2:27][N:28]3[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]3)[CH:22]=2)=[O:14])[CH:11]=1)([CH3:5])([CH3:4])[CH3:3]>ClCCl>[C:2]([C:6]1[CH:11]=[C:10]([NH:12][C:13](=[O:14])[C:15]2[CH:16]=[CH:17][C:18]([CH3:42])=[C:19]([O:20][C:21]3[CH:26]=[CH:25][N:24]=[C:23]([CH2:27][N:28]4[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]4)[CH:22]=3)[CH:41]=2)[C:9]([O:43][CH3:44])=[C:8]([CH:7]=1)[C:45]([O:47][CH3:48])=[O:46])([CH3:5])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67491494HCID 67491494, compound

Product 1

HCID 67491354HCID 67491354, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

At ambient temperature 1.4 mL of a 5-6 M isopropanolic hydrochloric acid solution are added to a solution of 270 mg tert-butyl 4-{4-[5-(5-tert-butyl-2-methoxy-3-methoxycarbonyl-phenylcarbamoyl)-2-methyl-phenoxy]-pyridin-2-ylmethyl}-piperazine-1-carboxylate in 6 ml dichloromethane. The solution is stirred overnight at ambient temperature and then diluted with dichloromethane. The solution is washed with saturated aqueous NaHCO3 solution and the aqueous phase is extracted once with dichloromethane. The combined organic phases are dried (Na2SO4), and the solvent is removed completely.

Workup

  1. washThe solution is washed with saturated aqueous NaHCO3 solution
  2. extractionthe aqueous phase is extracted once with dichloromethane
  3. dry with materialThe combined organic phases are dried (Na2SO4)
  4. customthe solvent is removed completely

Sources & evidence

ORD record
ord-40b8c970f8da4e35aca59861c6d39351
Source dataset
uspto-grants-2014_05
Patent number
US08735579B2

Reaction notes

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