Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4'-(Bromomethyl)-2-cyanobiphenyl | HCID 1501912 | — |
| Reactant | 1H-Imidazole-4,5-dicarboxylic acid, 2-propyl-, 4,5-diethyl ester | HCID 10286015 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 67024392 | HCID 67024392 | 100% |
Reaction Steps
Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate (30.7 g) obtained in Example 2 and 4′-(bromomethyl)biphenyl-2-carbonitrile (33.4 g) were dissolved in a mixture of acetone (45 ml) and N,N-dimethylacetamide (45 ml), followed by addition of potassium carbonate (29.3 g) to the reaction solution, and the reaction solution was stirred at 55° C. for 2 hours. The reaction solution was cooled to room temperature, followed by addition of water and toluene, and the organic layer was washed with water. The solvent was evaporated under reduced pressure to afford the title compound (53.8 g) as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08735598B2 |
|---|
| Source dataset | uspto-grants-2014_05 |
|---|
| ORD ID | ord-527f2fe0b8b945df8ccf707a9659b5c3 |
|---|
| Source note | uspto-grants-2014_05 |
|---|
