反应详情

温度

55 °C

Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate (30.7 g) obtained in Example 2 and 4′-(bromomethyl)biphenyl-2-carbonitrile (33.4 g) were dissolved in a mixture of acetone (45 ml) and N,N-dimethylacetamide (45 ml), followed by addition of potassium carbonate (29.3 g) to the reaction solution, and the reaction solution was stirred at 55° C. for 2 hours. The reaction solution was cooled to room temperature, followed by addition of water and toluene, and the organic layer was washed with water. The solvent was evaporated under reduced pressure to afford the title compound (53.8 g) as yellow crystals.

1. temperatureThe reaction solution was cooled to room temperature
2. washthe organic layer was washed with water
3. customThe solvent was evaporated under reduced pressure