Water → Ethyl 3-difluoromethyl-1-methyl-4-pyrazole carboxylate

HRID 1028848Notes

Reaction equation

HRID 1028848 reaction equation
[CH3:1][NH:2][NH2:3].O.[CH2:5]([O:7][C:8](=[O:19])/[C:9](=[CH:15]\OCC)/[C:10](=O)[CH:11]([F:13])[F:12])[CH3:6]>C1(C)C(C)=CC=CC=1>[F:12][CH:11]([F:13])[C:10]1[C:9]([C:8]([O:7][CH2:5][CH3:6])=[O:19])=[CH:15][N:2]([CH3:1])[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6061Methylhydrazine2×HCID 44185486HCID 44185486, compound

Product 1

HCID 11644126Ethyl 3-difluoromethyl-1-methyl-4-pyrazole carboxylate

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent2×

Procedure

A 0.25 mol solution of methylhydrazine 40% diluted in 50.0 g xylene and 4.7 g water was prepared. A solution of 0.25 mol of 2-[1-Ethoxy-meth-(Z)-ylidene]-4,4-difluoro-3-oxo-butyric acid ethyl ester in 100.0 g xylene was added to the methylhydrazine over 30-60 minutes at a temperature of 20-25° C. The reaction mixture was stirred for 15 min. The phases of the reaction mass were separated.

Workup

  1. customThe phases of the reaction mass were separated

Sources & evidence

ORD record
ord-8d5a2c6201d141b68e02ce3f67bed2fe
Source dataset
uspto-grants-2014_05
Patent number
US08735600B2

Reaction notes

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