反应详情

To a solution of 2-phenethylamine (0.28 mL, 2.195 mmol) in DCM (2.0 mL) was added 2-bromo-3-methylbenzoyl chloride (0.15 mL, 0.998 mmol) dropwise via syringe at ambient temperature. Mixture was allowed to stir overnight, then diluted with water (30 mL) and extracted with DCM (30 mL). The organic extract was washed with 1N HCl (2×25 mL) and 1N NaOH (2×25 mL) and dried over MgSO4. The solution was filtered and concentrated in vacuo to give 2-bromo-3-methyl-N-phenethylbenzamide as a white solid.

1. extractionextracted with DCM (30 mL)
2. extractionThe organic extract
3. washwas washed with 1N HCl (2×25 mL) and 1N NaOH (2×25 mL)
4. dry with materialdried over MgSO4
5. filtrationThe solution was filtered
6. concentrationconcentrated in vacuo