反应详情

温度

60 °C

To a sealed vessel containing 2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylbenzonitrile (0.040 g, 0.116 mmol) under N2 atmosphere was added a solution of propylmagnesium bromide, 2.0M in THF (0.232 mL, 0.465 mmol) via syringe at ambient temperature. The mixture was sonicated until all solids were in solution and then warmed vessel to 60° C. for 7 h. The mixture was concentrated, diluted with MeOH and purified on HPLC (10-100% MeCN/H2O with 0.1% TFA modifier) to afford 6-(2-(1-iminobutyl)-6-methylphenyl)-3-morpholinoquinolin-2-amine as white solid. MS (ESI, pos. ion) m/z: 389 (M+1).

1. customThe mixture was sonicated until all solids
2. concentrationThe mixture was concentrated
3. additiondiluted with MeOH
4. custompurified on HPLC (10-100% MeCN/H2O with 0.1% TFA modifier)