反应详情

A solution of 2-bromo-3-methylbenzoic acid (4.0 g, 18.60 mmol) in THF (93 mL) was cooled to 0° C. and LAH (1.41 g, 37.2 mmol) added by portion. After the reaction completed, aq. K/Na tartrate was added and the reaction stirred overnight. The aqueous layer was extracted with EtOAc and the organic layer was then washed with water and brine (3× ea.), dried over Na2SO4 and concentrated in vacuo to give (2-bromo-3-methylphenyl)methanol as a clear oil that was used without further purification.

1. extractionThe aqueous layer was extracted with EtOAc
2. washthe organic layer was then washed with water and brine (3× ea.)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo