Bromine → 1319196-91-2

HRID 1028986Notes

Reaction equation

HRID 1028986 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[Br:10]Br>C(Cl)Cl>[BrH:10].[Br:10][C:7]1[CH:8]=[C:2]([F:1])[CH:3]=[C:4]([CH3:9])[C:5]=1[NH2:6]

Participants

4

Reactant 2

HCID 24408BromineHCID 679824-Fluoro-2-methylaniline

Product 1

HCID 673242181319196-91-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-fluoro-2-methylaniline (5.0 g, 40.0 mmol) in DCM (100 mL) at RT was added bromine (2.06 mL, 40.0 mmol). The reagent appeared to react instantly and a solid precipitate was formed. The reaction was filtered and washed with DCM to give 2-bromo-4-fluoro-6-methylaniline hydrobromide as a light tan solid.

Workup

  1. customto react instantly
  2. customa solid precipitate was formed
  3. filtrationThe reaction was filtered
  4. washwashed with DCM

Sources & evidence

ORD record
ord-c8a10f06837c4d66a99954dad1018f3e
Source dataset
uspto-grants-2014_05
Patent number
US08735384B2

Reaction notes

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