Benzenepropanoic acid → Benzenepropanoyl chloride

HRID 1029059Notes

Reaction equation

HRID 1029059 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([CH2:11][CH2:12][C:13]([OH:15])=O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(Cl)Cl>[C:5]1([CH2:11][CH2:12][C:13]([Cl:3])=[O:15])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 107Benzenepropanoic acidHCID 24386Thionyl Chloride

Product 1

HCID 64801Benzenepropanoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (21.8 mL, 300 mmol) was added to a solution of 3-phenylpropionic acid (15 g, 99.9 mol) in DCM (40 mL) and was stirred overnight. The mixture was concentrated in vacuo to yield intermediate (7a), which was used in the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-330d91cd2fbb417aa728b6421d94e6d3
Source dataset
uspto-grants-2014_05
Patent number
US08735625B2

Reaction notes

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