反应详情

温度

40 °C

(3-Bromo-5-nitro-pyridin2-yl)-carbamic acid tert-butyl ester (100 mg, 0.31 mmol) and tin chloride (298 mg, 1.57 mmol) were dissolved in EtOH (3 mL), and stirred for 2 h at 40° C. The reaction solution was quenched with 2M NaOH, diluted with EtOAc, and filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated to provide (5-amino-3-bromo-pyridin-2-yl)-carbamic acid tert-butyl ester (85 mg, 94% yield) as a brown solid.

1. customThe reaction solution was quenched with 2M NaOH
2. additiondiluted with EtOAc
3. filtrationfiltered through an Extrelut column
4. washThe column was washed with EtOAc
5. concentrationthe filtrate was concentrated