反应详情

温度

60 °C

9-Amino-5H-benzo[c][1,8]naphthyridin-6-one (15 mg, 0.07 mmol), 2-napthylsulfonyl chloride (24 mg, 0.11 mmol), and N,N-diisopropylethylamine (0.04 mL, 0.21 mmol) were suspended in dioxane (2 mL), and stirred overnight at 60° C. The reaction mixture was diluted with MeOH, filtered, and purified via prep-LC-MS to provide 88 (5 mg, 17% yield) as a solid. LC-MS (M+H=402, obsd.=402). 1H NMR (400 MHz, d6-DMSO): δ 11.89 (s, 1H), 11.22 (s, 1H), 8.72 (d, 1H), 8.47 (d, 2H), 8.19 (d, 1H), 8.16 (dd, 1H), 8.12 (dd, 1H), 8.08 (dd, 1H), 7.99 (dd, 1H), 7.78 (dd, 1H), 7.65 (m, 2H), 7.42 (dd, 1H), 7.32 (m, 1H).

1. filtrationfiltered
2. custompurified via prep-LC-MS