(3-Chlorophenyl)boronic acid → HCID 58168319, compound

HRID 1029124Notes

Reaction equation

HRID 1029124 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=1>>[Cl:17][C:18]1[CH:23]=[C:22]([C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168319HCID 58168319, compoundYield 14%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 153 using Compound 83 (50 mg, 0.22 mmol) and 3-chloro-phenylboronic acid (44 mg, 0.33 mmol) to provide 155 (9 mg, 14% yield) as a white solid. LC-MS (M+H=307, obsd.=307).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-1e596e3030c54705b91d6a722163d3b2
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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