2-Amino-6-methoxybenzonitrile → HCID 58168273, compound

HRID 1029126Notes

Reaction equation

HRID 1029126 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:17][C:18]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[C:19]=1[C:20]#[N:21]>>[CH3:27][O:26][C:22]1[CH:23]=[CH:24][CH:25]=[C:18]([NH:17][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[C:19]=1[C:20]#[N:21]

Participants

3

Reactant 2

HCID 127157142-Amino-6-methoxybenzonitrileHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168273HCID 58168273, compoundYield 87%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 113 using Compound 83 (100 mg, 0.43 mmol) and 2-amino-6-methoxy-benzonitrile (77 mg, 0.52 mmol) to provide 157 (128 mg, 86% yield) as a yellow solid. LC-MS (M+H=343, obsd.=343).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e7c95535772a4e9ebc3d2ac4c35ec8f5
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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