3-Ethynylthiophene → HCID 58168309, compound

HRID 1029136Notes

Reaction equation

HRID 1029136 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[C:17]([C:19]1[CH:23]=[CH:22][S:21][CH:20]=1)#[CH:18]>>[S:21]1[CH:22]=[CH:23][C:19]([C:17]#[C:18][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:20]1

Participants

3

Reactant 2

HCID 35484223-EthynylthiopheneHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168309HCID 58168309, compoundYield 71.5%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 160 using Compound 83 (100 mg, 0.43 mmol) and 3-ethynyl-thiophene (70 mg, 0.65 mmol) to provide 167 (93 mg, 71% yield) as a white solid. LC-MS (M+H=303, obsd.=303).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-644f9271f0064f25b7d671b8cc791f11
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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