HCID 58168295, compound → HCID 69815544, compound

HRID 1029143Notes

Reaction equation

HRID 1029143 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][N:21]=[C:20]3[C:15]=2[C:16]2[CH:28]=[CH:27][CH:26]=[CH:25][C:17]=2[C:18](=[O:24])[NH:19]3)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[N:11]1([C:14]2[CH:23]=[CH:22][N:21]=[C:20]3[C:15]=2[C:16]2[CH:28]=[CH:27][CH:26]=[CH:25][C:17]=2[C:18](=[O:24])[NH:19]3)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 58168295HCID 58168295, compound

Product 1

HCID 69815544HCID 69815544, compoundYield 118.9%

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Conditions

Temperature
60 °C

Procedure

Compound 178 (70 mg, 0.18 mmol) was dissolved in 1.5 M HCl/MeOH (5 mL), and stirred for 4 h at 60° C. The reaction solution was concentrated, and the resulting precipitate was dried under vacuum to provide 179 (60 mg, 92% yield) as a white solid. LC-MS (M+H=281, obsd.=281).

Workup

  1. concentrationThe reaction solution was concentrated
  2. customthe resulting precipitate was dried under vacuum

Sources & evidence

ORD record
ord-2fcb9fd399304be9b000cde9afbf5e1a
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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