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Diisopropylethylamine → HCID 58168039、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| 反応物 | 1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid | HCID 21081527 | — |
| 反応物 | 1-(4-Amino-phenoxy)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58168367 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 溶媒 | Water ethylacetate | HCID 22728543 | — |
| 生成物 | HCID 58168039 | HCID 58168039 | 62.3% |
反応手順
Compound 137 (40 mg, 0.13 mmol), 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (37 mg, 0.16 mmol), BOP-Cl (50 mg, 0.20 mmol), and DIEA (0.07 mL, 0.40 mmol) were suspended in dioxane (2 mL), and stirred overnight at room temperature. The reaction mixture was diluted with EtOAc/H2O. The resulting precipitate was filtered, washed with EtOAc/H2O, and dried under vacuum to provide 181 (42 mg, 61% yield) as a white solid. LC-MS (M+H=519, obsd.=519).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08735584B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-3d52bb7c09c5435a8b31588ccdd7d5cf |
| 出典メモ | uspto-grants-2014_05 |