4-Amino-3-fluorophenol → HCID 58168352, compound

HRID 1029149Notes

Reaction equation

HRID 1029149 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][C:19]=1[F:25]>>[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:20][C:19]=1[F:25]

Participants

3

Reactant 2

HCID 27359194-Amino-3-fluorophenolHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168352HCID 58168352, compoundYield 83.6%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 182 using Compound 83 (250 mg, 1.08 mmol) and 4-amino-3-fluoro-phenol (276 mg, 2.17 mmol) to provide 185 (290 mg, 83% yield) as a solid. LC-MS (M+H=322, obsd.=322).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-761df4ccabcc462c9312538aaeacb077
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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