4-Chloro-2-fluoroaniline → HCID 58168354, compound

HRID 1029159Notes

Reaction equation

HRID 1029159 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[C:20]([F:25])[CH:19]=1>>[Cl:17][C:18]1[CH:24]=[CH:23][C:21]([NH:22][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[C:20]([F:25])[CH:19]=1

Participants

3

Reactant 2

HCID 938984-Chloro-2-fluoroanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168354HCID 58168354, compoundYield 79.4%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 4-chloro-2-fluoroaniline (95 mg, 0.65 mmol) to provide 195 (116 mg, 79% yield) as a white solid. LC-MS (M+H=340, obsd.=340).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-8f14fd96d2ac49d0a1bbc3fab8cabb20
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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