o-Phenetidine → HCID 58168049, compound

HRID 1029162Notes

Reaction equation

HRID 1029162 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[CH2:17]([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH2:22])[CH3:18]>>[CH2:17]([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH:22][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2)[CH3:18]

Participants

3

Reactant 2

HCID 7203o-PhenetidineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168049HCID 58168049, compoundYield 86.3%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2-ethoxyaniline (119 mg, 0.87 mmol) to provide 198 (123 mg, 86% yield) as a white solid. LC-MS (M+H=332, obsd.=332).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e761ac897a7c4c03bf0470a5d3df1337
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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