4-Chloro-2,5-dimethoxyaniline → HCID 58168058, compound

HRID 1029167Notes

Reaction equation

HRID 1029167 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[C:24]([O:25][CH3:26])=[CH:23][C:21]([NH2:22])=[C:20]([O:27][CH3:28])[CH:19]=1>>[Cl:17][C:18]1[C:24]([O:25][CH3:26])=[CH:23][C:21]([NH:22][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[C:20]([O:27][CH3:28])[CH:19]=1

Participants

3

Reactant 2

HCID 228334-Chloro-2,5-dimethoxyanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168058HCID 58168058, compoundYield 48.7%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 4-chloro-2,5-di-methoxyaniline (122 mg, 0.65 mmol) to provide 203 (80 mg, 48% yield) as a white solid. LC-MS (M+H=382, obsd.=382).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-96f590906932474e8175480b028b61b9
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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