4-Chloro-3-iodopyridin-2-amine → HCID 58168232, compound

HRID 1029180Notes

Reaction equation

HRID 1029180 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1I.C[O:11][C:12]([C:14]1[CH:19]=[C:18]([OH:20])[CH:17]=[CH:16][C:15]=1B(O)O)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:3]=1[C:15]1[CH:16]=[CH:17][C:18]([OH:20])=[CH:19][C:14]=1[C:12](=[O:11])[NH:8]2

Participants

3

Reactant 2

HCID 229365964-Chloro-3-iodopyridin-2-amineHCID 68648691HCID 68648691, compound

Product 1

HCID 58168232HCID 58168232, compoundYield 17.2%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 1 using 4-chloro-3-iodopyridin-2-amine (500 mg, 1.96 mmol) and 2-methoxycarbonyl-4-hydroxy-phenylboronic acid (765 mg, 2.75 mmol) to provide 217 (83 mg, 17% yield) as a white solid. LC-MS (M+H=247, obsd.=247).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e810c770b1f14f1383cdc1ee54f17254
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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