1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one → HCID 58168255, compound

HRID 1029192Notes

Reaction equation

HRID 1029192 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[N:17]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([OH:27])[CH:25]=2)[CH:20]=[CH:19][CH:18]=1>>[N:17]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([O:27][C:2]3[CH:11]=[CH:10][N:9]=[C:8]4[C:3]=3[C:4]3[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=3[C:6](=[O:12])[NH:7]4)[CH:25]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-oneHCID 1354268667-Hydroxyquinoline

Product 1

HCID 58168255HCID 58168255, compoundYield 69%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 182 using 83 (50 mg, 0.22 mmol) and quinolin-7-ol (63 mg, 0.43 mmol) to provide 229 (51 mg, 69% yield) as a tan solid. LC-MS (M+H=340, obsd.=340).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-43be2edfbb6a4146a24fa437ea2ef301
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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