4-Fluoroaniline → HCID 58168190, compound

HRID 1029198Notes

Reaction equation

HRID 1029198 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[F:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:24]=[CH:23][C:21]([NH:22][C:2]2[CH:16]=[CH:15][C:5]3[C:6](=[O:14])[NH:7][C:8]4[C:13]([C:4]=3[CH:3]=2)=[CH:12][CH:11]=[CH:10][N:9]=4)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58168190HCID 58168190, compoundYield 25.3%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 231 using 6 (50 mg, 0.22 mmol) and 4-fluoroaniline (0.03 mL, 0.33 mmol) to provide 235 (17 mg, 23% yield) as a green/brown solid. LC-MS (M+H=306, obsd.=306).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-11369d75c5b74313aacbf396365baa3b
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

Loading…