m-Toluidine → HCID 58168041, compound

HRID 1029204Notes

Reaction equation

HRID 1029204 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1>>[C:20]1([CH3:24])[CH:21]=[CH:22][CH:23]=[C:18]([NH:17][C:2]2[CH:16]=[CH:15][C:5]3[C:6](=[O:14])[NH:7][C:8]4[C:13]([C:4]=3[CH:3]=2)=[CH:12][CH:11]=[CH:10][N:9]=4)[CH:19]=1

Participants

3

Reactant 2

HCID 7934m-ToluidineHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58168041HCID 58168041, compoundYield 22.4%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 231 using 6 (100 mg, 0.43 mmol) and m-toluidine (0.07 mL, 0.65 mmol) to provide 241 (29 mg, 20% yield) as a black powder. LC-MS (M+H (parent)=302, obsd.=302).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-0fbd2dc9ed9343f6bf6934122b15c82e
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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