4-Isopropylaniline → HCID 58168288, compound

HRID 1029205Notes

Reaction equation

HRID 1029205 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[CH:17]([C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)([CH3:19])[CH3:18]>>[CH:17]([C:20]1[CH:26]=[CH:25][C:23]([NH:24][C:2]2[CH:16]=[CH:15][C:5]3[C:6](=[O:14])[NH:7][C:8]4[C:13]([C:4]=3[CH:3]=2)=[CH:12][CH:11]=[CH:10][N:9]=4)=[CH:22][CH:21]=1)([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 74644-IsopropylanilineHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58168288HCID 58168288, compoundYield 16.9%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 231 using 6 (100 mg, 0.43 mmol) and 4-isopropylaniline (0.09 mL, 0.65 mmol) to provide 242 (24 mg, 15% yield) as a brown solid. LC-MS (M+H (parent)=330, obsd.=330).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-937391280b8a4ce5aaba192a420637dd
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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