1-Ethynyl-2,4-difluorobenzene → HCID 58168062, compound

HRID 1029214Notes

Reaction equation

HRID 1029214 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[C:17]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=1[F:26])#[CH:18]>>[F:26][C:20]1[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:19]=1[C:17]#[C:18][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 50638201-Ethynyl-2,4-difluorobenzeneHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168062HCID 58168062, compoundYield 63.7%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 1-ethynyl-2,4-difluorobenzene (90 mg, 0.65 mmol) to provide 252 (91 mg, 63% yield) as a tan solid. LC-MS (M+H=333 obsd.=333).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-9b4064af011f4c369a82e20a2a54414f
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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