HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynyl-2,4-difluorobenzene → HCID 58168062, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynyl-2,4-difluorobenzene | HCID 5063820 | — |
| Reactant | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| Product | HCID 58168062 | HCID 58168062 | 63.7% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 1-ethynyl-2,4-difluorobenzene (90 mg, 0.65 mmol) to provide 252 (91 mg, 63% yield) as a tan solid. LC-MS (M+H=333 obsd.=333).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-9b4064af011f4c369a82e20a2a54414f |
| Source note | uspto-grants-2014_05 |