1-Ethynyl-4-(trifluoromethyl)benzene → HCID 58168131, compound

HRID 1029217Notes

Reaction equation

HRID 1029217 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[C:17]([C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1)#[CH:18]>>[F:26][C:25]([F:27])([F:28])[C:22]1[CH:21]=[CH:20][C:19]([C:17]#[C:18][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 43482951-Ethynyl-4-(trifluoromethyl)benzeneHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168131HCID 58168131, compoundYield 48%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 4-ethynyl-α,α,α-trifluorotoluene (0.11 mL, 0.65 mmol) to provide 255 (75 mg, 48% yield) as a tan solid. LC-MS (M+H=365 obsd.=365).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-cc26cf3a6e60402eabc5100552dcf912
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

Loading…