HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynyl-4-(trifluoromethyl)benzene → HCID 58168131, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynyl-4-(trifluoromethyl)benzene | HCID 4348295 | — |
| Reactant | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| Product | HCID 58168131 | HCID 58168131 | 48% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 4-ethynyl-α,α,α-trifluorotoluene (0.11 mL, 0.65 mmol) to provide 255 (75 mg, 48% yield) as a tan solid. LC-MS (M+H=365 obsd.=365).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-cc26cf3a6e60402eabc5100552dcf912 |
| Source note | uspto-grants-2014_05 |